The double-faced role of P2X7 receptors in toxin-induced animal models of Parkinson’s disease
نویسندگان
چکیده
Methods PC12 cells and primary mesencephalic neurons were used in culture, and the striatum and the substantia nigra were prepared from wild-type and P2X7 receptor knockout mice. Rotenone and 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) treatments were applied in vitro and in vivo to reproduce neurochemical hallmarks of PD. Receptor expression, cell survival indicators, and endogenous biogenic amine, amino acid, adenine nucleotide and endocannabinoid contents were analyzed.
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